The Military Support Group by Amanda Springer

Canadian Institutes of Health Research Science Policy Fellowship ProgramĢ014-2017 Project co-director, “Options for Addressing Consideration of Chronic Disease Endpoints for Dietary Reference Intakes (DRIs)”. Canadian Institutes of Health Research Nutrition, Food and Health Committee - Project Grant CompetitionĢ016-2017 Workshop co-organizer, “Periconceptional intake of folic acid among low-risk women: aligning prenatal supplement content with current expert guidelines”. Washington, DC: The National Academies Press.Ģ017, 2018 Peer reviewer. Harmonization of Approaches to Nutrient Reference Values: Applications to Young Children and Women of Reproductive Age. National Academies of Sciences, Engineering, and Medicine.

US-Canada Special Nutrient Requirements in Disease States Federal Working GroupĢ018 Reviewer. The American Journal of Clinical NutritionĢ018-present Co-Chair.

I am also actively involved in policy work related to food fortification and supplement use, and international standard setting including the Dietary Reference Intakes.Ģ018-present Associate Editor. Using nationally-representative population health data, we also assess the folate and B vitamin status of Canadians, and identify socioeconomic, dietary and genetic determinants of status in the Canadian population. Using in vitro and in vivo models, my lab examines the biochemical, genetic and epigenetic mechanisms underpinning folate-dependent diseases with a particular interest in the effect of maternal and paternal nutrition on fertility, and its effect on the health of their offspring. Methionine is used to form S-adenosylmethionine (AdoMet) the major methyl donor in the cell required for DNA, RNA and histone methylation, which impacts genome stability and the expression of epigenetically regulated genes. Nucleotide pool imbalances (too much or too little of one nucleotide) can result in cytotoxicity, DNA mutagenesis, genome instability and changes in gene expression. Folate-mediated 1C metabolism provides 1C groups for the de novo synthesis of purines, thymidylate, and methionine. Folic acid (folate), along with the other essential B vitamins, is required for DNA synthesis and cellular methylation reactions. My lab studies folate-mediated one-carbon (1C) metabolism in health and disease.

The Military Support Group by Amanda Springer